What is the cause of syphilis kidney disease?

The infection and pathogenesis of syphilis are characterized by periodic latency and recurrence, and the reason is related to the production of immunity. When the body's immunity declines, Treponema pallidum can invade certain parts of the body. Sylipid-related nephropathy mainly occurs in acquired secondary syphilis, and its incidence rate is low. The clinical manifestations of acquired syphilis renal damage are diverse, such as acute nephrotic syndrome squirting dildo , membranous glomerulonephropathy, acute progressive glomerulonephritis, etc., and the incidence of the latter is not high, but patients with newly occurring nephrotic syndrome should be routinely screened for syphilis to rule out the possibility of syphilis. So, what is the cause of syphilis kidney disease?

Causes of the disease:

The pathogen of this disease is Treponema pallidum, which belongs to the genus Treponema of the family Treponema microspira. The pathogen of syphilis is also named Treponema pallidum because its body fluids are transparent, the surface is smooth, and the refractive power is strong and is not easy to dye. Spirulina pallidus is a slender spiral microorganism. When observed with oil microscope, it can be found that it moves in the following ways. Rotating forward relies on its long axis to rotate forward, which is the most important way to invade the human body; swinging the body in a wave-like manner. Forward, is the most common way of exercise; The other method is to stretch and retract the rotation to move its body vibrator for women , change the rotation to crawl forward. The helix moves very quickly my old ass , often in a mixed movement of the above three methods. Spirulina pale can parasitize and grow for a long time in the body. controller vibrator , reproduce, has strong fecundity and pathogenicity, but its vitality and resistance are very weak after leaving the human body. It is very sensitive to dryness, temperature, humidity and chemicals. It dies within 1 to 2 hours in a dry environment. It is sensitive to high temperatures and has a strong tolerance to low temperatures. Death immediately at 100℃; survival for 3 to 5 minutes at 60℃; rapid death under sunlight; survival for 1 to 2 days at 0℃; survival for several years at-78℃ and death immediately in soapy water; Death in 0.1% phenol solution 15 minutes; death in 5% formaldehyde solution 5 minutes; can be killed immediately with 1:5000 mercury oxide solution;0.1% fresh clean and kill solution and potassium permanganate solution both have good killing effect.

Pathogenesis:

See the relevant chapters for the pathogenesis of syphilis. The pathogenesis of syphilis associated nephropathy is mainly due to the formation and deposition of immune complexes under the renal epithelium, causing renal damage. Currently, immune complexes (such as complement C1q-binding activity and anti-complement substances) are also found in the peripheral blood of patients, suggesting that these immune complexes in peripheral blood are of great significance to the pathogenesis of sylip-associated nephropathy.
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