Molecular switches that cause infertility and abortion help develop contraceptives

Researchers at Imperial College London published a paper in the recent issue of the journal Nature Medicine saying that they found that the content of an enzyme called SGK1 in a woman's endometrium directly affects a woman's fertility. If the content is too high, it can lead to infertility. If the content is too low, it can easily lead to miscarriage. The discovery will not only help the research and treatment of infertility or habitual abortion, but also help the development of new contraceptive drugs.

Infertility is a huge problem for many families in modern society. Studies have shown that nearly one in six women have difficulty conceiving due to various reasons, and one percent of women will habitually miscarry after conception.

Researchers at Imperial College London in the United Kingdom studied the physiological indicators of 106 women with unexplained infertility or habitual abortion and found that their troubles are directly related to the level of SGK1 in their endometrium. Women with unexplained infertility have higher SGK1 levels in the endometrium than ordinary people penis pumping , while those with habitual abortion have lower SGK1 levels than ordinary people. Through further mouse experiments, the researchers found that during the pregnancy period of mice, the level of SGK1 in the endometrium of mice decreased. During this period rose toy , if a copy of the SGK1 gene was injected into mouse endometrial cells to increase the level of the protein, it would cause mice to fail to conceive; and if the expression of SGK1 gene in mice was blocked and its level was reduced dog dildo chastity cage , although it would be fine for mice to conceive, it would make the endometrium more fragile, which would lead to intrauterine bleeding and lead to abortion.

Researchers said that SGK1, as a fertility molecular switch, has a direct impact on a woman's fertility and is the key to successful pregnancy. Reducing SGK1 levels in endometrial cells of infertile women with drugs before undergoing artificial conception can improve the success rate of artificial conception. Increasing SGK1 levels can be regarded as a new contraceptive method that can be used to develop new contraceptive drugs.
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