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What examination should diagnostic lymphogranuloma do?

Venereal lymphoid granuloma, also known as inguinal lymphogranuloma, the fourth venereal disease, tropical or climatic transverse disease dildo hero realistic dildo , Frey's disease, together with syphilis, gonorrhea, chancre known as the four major venereal diseases. The disease is caused by Chlamydia trachomatis, which is divided into two types: Chlamydia trachomatis and Chlamydia psittaci. Chlamydia trachomatis is associated with venereal lymphogranuloma. According to different serological reactions, Chlamydia trachomatis can be divided into 15 serum types, including L1, L2 and L3, which can cause lymphogranuloma venereum.

Diagnostic lymphogranuloma is mainly based on the patient's history, clinical manifestations and laboratory examination.

1. History of unclean sexual intercourse or contact with close pollutants.

2. Superficial erosion and ulcers appeared in the genitals.

3. After 4 weeks, there were bilateral inguinal lymphadenitis, groove sign and sprinkler-like fistula, and scars were left after recovery.

4. Laboratory examination is necessary for the diagnosis of venereal lymphoid granuloma. First of all, serological examination should be done, which is necessary for diagnosis and determination of curative effect. If possible, it is necessary to culture Chlamydia trachomatis and further determine the serotype of chlamydia. In addition, Frei skin test and histopathological examination can be carried out according to specific conditions.

Serological tests for the diagnosis of venereal lymphogranuloma are as follows:

1. Complement fixation test

The antigen used is a group antigen produced by the Institute of Microbiology in Switzerland. It is an important serological diagnosis method for the disease and can detect two kinds of antibodies: Chlamydia trachomatis antibody and Chlamydia psittaci antibody. Because chlamydia infection is common in the population, the positive result of this test is helpful to the diagnosis, but the diagnosis cannot be determined by the results. The serum titer of the patients was high, mostly at 1:64 or above, but the serum titer was low when Chlamydia trachomatis was infected. Generally speaking, the serum titer of 1:8 or 1:6 has hint significance for the diagnosis of the disease, while 1:64 or above has diagnostic significance. The serum titer of convalescent patients decreased. In addition, the results of serum tests are not completely parallel to the response to antibiotic treatment.

2. Microimmunofluorescence test

This test has a certain sensitivity and specificity, and it is more sensitive and specific than complement fixation test. It can detect specific antibodies against different serotypes of chlamydia and can be used to distinguish this disease from other chlamydia infection. It usually makes sense if the titer is greater than 512. However, due to the limitation of test conditions, it is difficult to be widely used at present.

3. Convective immunoelectrophoresis

This is a simple, rapid and specific test for the detection of chlamydia antibody. About 90% of patients can be confirmed by this trial.

4. Pathogen culture

The enlarged lymph node puncture should be inoculated into the yolk sac of chicken embryo, or for tissue (cell) culture or intracranial inoculation in mice. Positive patients have diagnostic value. Bacterial culture and smear Gram staining are also required to exclude lymph node inflammation caused by staphylococci or other bacteria.

Specimens of culturally diseased lymphogranuloma are often taken from the urethra, rectum or enlarged lymph nodes in men. In women, it is mainly taken from the rectum and cervix. Before inoculation, the growth medium was diluted with 1 ∶ 1 to avoid toxicity to cells. Specimens should be treated with antibiotics before inoculation. Commonly used antibiotics are gentamicin, vancomycin, streptomycin and nystatin. Since STD lymphogranuloma chlamydia can infect neighboring cells without centrifugation, resulting in cell lysis lesbian vibrator , this trait helps to identify suspected isolates.

5. Biopsy

The pathological changes of skin, mucosal lesions or lymph nodes were observed, which is of significance for diagnosis.

6. Other

There may be high r globulinemia, inverted albumin / globulin ratio, increased lgA and lgG, mild anemia big ass anal , leukocytosis, accelerated ESR, false positive syphilis serum test, positive cold sedimentation globulin and rheumatoid factor, etc.
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