Syphilis is a chronic, systemic sexually transmitted disease caused by Treponema pallidum infection. It is mainly transmitted through sexual intercourse. Secondary syphilis is caused by Treponema pallidum spreading throughout the body through the blood stream, causing most small lesions in various organs, often involving the skin
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The earliest symptoms of secondary syphilis can follow one week after the hard chancre appears
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Generally
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Secondary syphilis can also be caused by blood-borne transmission. If the blood donor is a latent syphilis patient, the blood he or she provides may contain Treponema pallidum. Once infused into the blood recipient, infection can occur. Such patients do not develop symptoms of primary syphilis, but directly develop symptoms of secondary syphilis. Therefore, it is very important to conduct serological screening for syphilis on blood donors.
There are four reasons for the recurrence of secondary syphilis:
(1) Treatment is not standardized. During the period of second-stage early-onset syphilis, second-stage syphilis will also recur due to lack of timely treatment or insufficient treatment dose or insufficient duration of treatment.
(2) It is related to the patient's physique and immunity. For example, people who are elderly and frail, or who have also suffered from diabetes and tumors, and who have long-term use of immunosuppressants and hormones, are more likely to develop secondary recurrence of syphilis.
(3) Because secondary syphilis rash is not itching or painful and can resolve spontaneously, and is often misdiagnosed as other skin diseases, treatment is often ignored and treatment opportunities are delayed.
(4) Limitations in the choice of treatment drugs: During the period of second-stage early syphilis, penicillin preparations could not be chosen for various reasons, but penicillin replacement drugs such as tetracycline, doxycycline, erythromycin or other types of antibiotics were chosen, which can also lead to the recurrence of second-stage syphilis.
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