Causes of sexually transmitted lymphogranuloma

Sexually transmitted lymphogranuloma, also known as inguinal lymphogranuloma, fourth sexually transmitted disease, tropical or climatic transverse disease, and Fre1 disease. Together with syphilis, gonorrhea, and chancroid, they are called the four major sexually transmitted diseases.

The disease is caused by chlamydia, which is divided into two types: chlamydia trachomatis and chlamydia psittaci. Associated with sexually transmitted lymphogranuloma is Chlamydia trachomatis. According to different serological reactions, Chlamydia trachomatis can be divided into 15 serological types. Among them, four types A, B, Ba and C can cause trachoma, serological types D-K can cause non-gonococcal urethritis, and three serological types L1, L2 and L3 can cause sexually transmitted lymphogranuloma. Because these types of chlamydia that cause venereal lymphogranuloma were discovered by Japanese scholar Miyagawa as early as 1936, some people specifically call them Miyagawa bodies. LGV is widely distributed all over the world and is most common in tropical areas. However, the incidence rate in the world has dropped significantly and is rare in our country. my country's sexually transmitted diseases surveillance system reported 389 cases in 2005. In recent years, LGV has been reported to have a significant upward trend bdsm chastity , but the reported cases have not been confirmed by serological testing or culture.

LGV has heat-labile endotoxin bullet vibrator , as well as heat-labile and heat-labile antigens, while hot antigens are not destroyed when heated to 100 ° C. It is an antigen shared with Chlamydia psittaci and others. Injecting LGV into the brain of mice or monkeys can cause meningitis in animals, but not in the brain of birds vaccinated.

After infection with LGV, complement binding antibodies appear in the serum. Humans are the only natural host of the disease and invade the skin and lymph nodes. LGV serotypes are highly invasive and cause many systemic lesions. Unlike other Chlamydia trachomatis serotypes, which are mainly confined to the mucosa, LGV pathogens can invade macrophages. Cell-mediated immunity and humoral immunity can limit but not completely eliminate the spread of local and systemic infections. Even at advanced stages, pathogens can be isolated from infected tissue.

The pathogen of this disease has low resistance and can be killed by general disinfectants. It survives in vitro for 2-3 days and can be inactivated at 50℃ for 30 minutes or 90℃-100 ℃ for 1 minute. 70% ethanol, 2% lysol best vibrator , 2% chloramine dog dildo , ultraviolet light or dry room temperature cannot survive.

It is mainly transmitted through sexual contact and occasionally accidentally transmitted through pollution or experiments. There are complications such as primary genital sores, local lymphadenopathy, advanced elephantiasis and rectal stricture. Due to the extensive development of chemotherapy, the disease is now rare.

It is mainly infected through sexual behavior. The peak incidence of LGV is consistent with the peak age of sexual activity between 20 and 30 years old. The contact infection rate of the disease is much lower than that of gonorrhea and syphilis. Early manifestations are more common in men than in women, while women often show up as late complications.

During special Giemsa staining, these chlamydia that cause lymphogranuloma venereal can be seen in the cytoplasm of multinucleated or monocyte cells, inclusion bodies with a purple polyhedral structure, about 4 - 5ttm long and about 0.125 - 0.175 um wide. Sometimes they are distributed in clusters outside the cytoplasm. These chlamydia in vitro are not resistant to drying or heat, and can be killed by ultraviolet light and antiseptic disinfectants.
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